APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here APOBEC3B proteomics reveal interactions with a surprising number of R-loop factors. Biochemical experiments show APOBEC3B bindin...

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Bibliographic Details
Main Authors:	McCann, JL, Cristini, A, Law, EK, Tellier, M, Beghè, C, Murphy, S, Gromak, N
Format:	Journal article
Language:	English
Published:	Springer Nature 2023

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