Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

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Increased production of reactive oxygen species and loss of endothelial NO bioactivity are key features of vascular disease states such as diabetes mellitus. Tetrahydrobiopterin (BH4) is a required cofactor for eNOS activity; pharmacologic studies suggest that BH4 may mediate some of the adverse eff...

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Bibliographic Details
Main Authors:	Alp, N, Mussa, S, Khoo, J, Cai, S, Guzik, T, Jefferson, A, Goh, N, Rockett, K, Channon, K
Format:	Journal article
Language:	English
Published:	2003

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