Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

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Increased production of reactive oxygen species and loss of endothelial NO bioactivity are key features of vascular disease states such as diabetes mellitus. Tetrahydrobiopterin (BH4) is a required cofactor for eNOS activity; pharmacologic studies suggest that BH4 may mediate some of the adverse eff...

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Bibliografiske detaljer
Main Authors:	Alp, N, Mussa, S, Khoo, J, Cai, S, Guzik, T, Jefferson, A, Goh, N, Rockett, K, Channon, K
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
af: Alp, N, et al.
Udgivet: (2003)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I over-expression
af: Alp, N, et al.
Udgivet: (2003)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
af: Bendall, J, et al.
Udgivet: (2004)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
af: Alp, N, et al.
Udgivet: (2004)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
af: Alp, N, et al.
Udgivet: (2003)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
af: Bendall, J, et al.
Udgivet: (2005)

Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
af: Wang, W, et al.
Udgivet: (2008)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
af: Chuaiphichai, S, et al.
Udgivet: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
af: Chuaiphichai, S, et al.
Udgivet: (2014)

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
af: Tatham, A, et al.
Udgivet: (2009)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
af: Chuaiphichai, S, et al.
Udgivet: (2014)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
af: Cai, S, et al.
Udgivet: (2002)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
af: Chuaiphichai, S, et al.
Udgivet: (2021)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension
af: Du, Y, et al.
Udgivet: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension\
af: Du, Y, et al.
Udgivet: (2005)

Endothelial-specific GTP cyclohydrolase I overexpression prevents blood pressure progression in salt-sensitive hypertension
af: Chen, A, et al.
Udgivet: (2005)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
af: Cai, S, et al.
Udgivet: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
af: Cai, S, et al.
Udgivet: (2004)

Endothelial-specific GTP cyclohydrolase overexpression reduces blood pressure in salt-sensitive hypertension
af: Chen, A, et al.
Udgivet: (2006)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
af: Adlam, D, et al.
Udgivet: (2007)

Systemic adenovirus-mediated gene transfer of human GTP cyclohydrolase-1 increases liver, plasma and aortic tetrahydrobiopterin levels in mice
af: Alp, N, et al.
Udgivet: (2002)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
af: Carnicer, R, et al.
Udgivet: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
af: Carnicer, R, et al.
Udgivet: (2012)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
af: Alp, N, et al.
Udgivet: (2004)

Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
af: Liao, S, et al.
Udgivet: (2007)

GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.
af: Meininger, C, et al.
Udgivet: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
af: Cai, S, et al.
Udgivet: (2005)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
af: Cai, S, et al.
Udgivet: (2004)

Cardiomyocyte-Targeted Overexpression of GTP Cyclohydrolase-1 Increases Myocyte Lusitropy and Reduces Superoxide Production
af: Carnicer, R, et al.
Udgivet: (2010)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
af: Alp, N, et al.
Udgivet: (2004)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
af: Alp, N, et al.
Udgivet: (2002)

PRESERVATION OF ENDOTHELIAL GTP CYCLOHYDROLASE I ACTIVITY AND IMPROVEMENT OF RENAL NITRIC OXIDE AVAILABILITY PREVENT THE DEVELOPMENT OF DIABETIC NEPHROPATHY
af: Satoh, M, et al.
Udgivet: (2012)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
af: Adlam, D, et al.
Udgivet: (2012)

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
af: Crabtree, M, et al.
Udgivet: (2009)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
af: Khoo, J, et al.
Udgivet: (2004)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
af: Adlam, D, et al.
Udgivet: (2012)

Endothelium-targeted GTP cyclohydrolase I overexpression inhibits wire injury-induced restenosis in mouse carotid artery
af: Chen, A, et al.
Udgivet: (2005)

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation
af: Carnicer, R, et al.
Udgivet: (2011)

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
af: Du, Y, et al.
Udgivet: (2008)

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
af: Antoniades, C, et al.
Udgivet: (2011)