Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
The total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels–Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air and vis...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2017
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| _version_ | 1797072995790880768 |
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| author | De Silvestro, I Drew, S Nichol, G Duarte, F Lawrence, A |
| author_facet | De Silvestro, I Drew, S Nichol, G Duarte, F Lawrence, A |
| author_sort | De Silvestro, I |
| collection | OXFORD |
| description | The total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels–Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air and visible light. These results indicate that this natural product is likely the result of spontaneous (non‐enzyme‐mediated) reactivity. |
| first_indexed | 2024-03-06T23:15:45Z |
| format | Journal article |
| id | oxford-uuid:6712829a-468a-49e8-9601-c5084c13002c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:15:45Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:6712829a-468a-49e8-9601-c5084c13002c2022-03-26T18:35:51ZTotal synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6712829a-468a-49e8-9601-c5084c13002cEnglishSymplectic Elements at OxfordWiley2017De Silvestro, IDrew, SNichol, GDuarte, FLawrence, AThe total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels–Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air and visible light. These results indicate that this natural product is likely the result of spontaneous (non‐enzyme‐mediated) reactivity. |
| spellingShingle | De Silvestro, I Drew, S Nichol, G Duarte, F Lawrence, A Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis |
| title | Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
|
| title_full | Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
|
| title_fullStr | Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
|
| title_full_unstemmed | Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
|
| title_short | Total synthesis of a Dimeric Thymol derivative isolated from Arnica sachalinensis
|
| title_sort | total synthesis of a dimeric thymol derivative isolated from arnica sachalinensis |
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