No genetic overlap between circulating iron levels and Alzheimer's disease
Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an e...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
IOS Press
2017
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| _version_ | 1826276564875083776 |
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| author | Lupton, MK Benyamin, B Proitsi, P Nyholt, DR Ferreira, MA Montgomery, GW Heath, AC Madden, PA Medland, SE Gordon, SD GERAD1 Consortium Alzheimer’s Disease Neuroimaging Initiative Lovestone, S Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Vellas, B Powell, JF Bush, AI Wright, MJ Martin, NG Whitfield, JB |
| author_facet | Lupton, MK Benyamin, B Proitsi, P Nyholt, DR Ferreira, MA Montgomery, GW Heath, AC Madden, PA Medland, SE Gordon, SD GERAD1 Consortium Alzheimer’s Disease Neuroimaging Initiative Lovestone, S Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Vellas, B Powell, JF Bush, AI Wright, MJ Martin, NG Whitfield, JB |
| author_sort | Lupton, MK |
| collection | OXFORD |
| description | Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. |
| first_indexed | 2024-03-06T23:15:52Z |
| format | Journal article |
| id | oxford-uuid:671aae93-8727-4701-bb74-d83f8f8fe771 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:15:52Z |
| publishDate | 2017 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | oxford-uuid:671aae93-8727-4701-bb74-d83f8f8fe7712022-03-26T18:36:14ZNo genetic overlap between circulating iron levels and Alzheimer's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:671aae93-8727-4701-bb74-d83f8f8fe771EnglishSymplectic Elements at OxfordIOS Press2017Lupton, MKBenyamin, BProitsi, PNyholt, DRFerreira, MAMontgomery, GWHeath, ACMadden, PAMedland, SEGordon, SDGERAD1 ConsortiumAlzheimer’s Disease Neuroimaging InitiativeLovestone, STsolaki, MKloszewska, ISoininen, HMecocci, PVellas, BPowell, JFBush, AIWright, MJMartin, NGWhitfield, JBIron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. |
| spellingShingle | Lupton, MK Benyamin, B Proitsi, P Nyholt, DR Ferreira, MA Montgomery, GW Heath, AC Madden, PA Medland, SE Gordon, SD GERAD1 Consortium Alzheimer’s Disease Neuroimaging Initiative Lovestone, S Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Vellas, B Powell, JF Bush, AI Wright, MJ Martin, NG Whitfield, JB No genetic overlap between circulating iron levels and Alzheimer's disease |
| title | No genetic overlap between circulating iron levels and Alzheimer's disease |
| title_full | No genetic overlap between circulating iron levels and Alzheimer's disease |
| title_fullStr | No genetic overlap between circulating iron levels and Alzheimer's disease |
| title_full_unstemmed | No genetic overlap between circulating iron levels and Alzheimer's disease |
| title_short | No genetic overlap between circulating iron levels and Alzheimer's disease |
| title_sort | no genetic overlap between circulating iron levels and alzheimer s disease |
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