High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure

BACKGROUND:Humanity has become largely dependent on artemisinin derivatives for both the treatment and control of malaria, with few alternatives available. A Plasmodium falciparum phenotype with delayed parasite clearance during artemisinin-based combination therapy has established in Southeast Asia...

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Bibliographic Details
Main Authors: Tyagi, R, Gleeson, P, Arnold, L, Tahar, R, Prieur, E, Decosterd, L, Pérignon, J, Olliaro, P, Druilhe, P
Format: Journal article
Language:English
Published: BioMed Central 2018