Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.

The orbital prefrontal cortex is thought to be involved in behavioral flexibility in primates, and human neuroimaging studies have identified orbital prefrontal activation during episodic memory encoding. The goal of the present study was to ascertain whether deficits in strategy implementation and...

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Asıl Yazarlar: Baxter, MG, Gaffan, D, Kyriazis, D, Mitchell, A
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2007
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author Baxter, MG
Gaffan, D
Kyriazis, D
Mitchell, A
author_facet Baxter, MG
Gaffan, D
Kyriazis, D
Mitchell, A
author_sort Baxter, MG
collection OXFORD
description The orbital prefrontal cortex is thought to be involved in behavioral flexibility in primates, and human neuroimaging studies have identified orbital prefrontal activation during episodic memory encoding. The goal of the present study was to ascertain whether deficits in strategy implementation and episodic memory that occur after ablation of the entire prefrontal cortex can be ascribed to damage to the orbital prefrontal cortex. Rhesus monkeys were preoperatively trained on two behavioral tasks, the performance of both of which is severely impaired by the disconnection of frontal cortex from inferotemporal cortex. In the strategy implementation task, monkeys were required to learn about two categories of objects, each associated with a different strategy that had to be performed to obtain food reward. The different strategies had to be applied flexibly to optimize the rate of reward delivery. In the scene memory task, monkeys learned 20 new object-in-place discrimination problems in each session. Monkeys were tested on both tasks before and after bilateral ablation of orbital prefrontal cortex. These lesions impaired new scene learning but had no effect on strategy implementation. This finding supports a role for the orbital prefrontal cortex in memory but places limits on the involvement of orbital prefrontal cortex in the representation and implementation of behavioral goals and strategies.
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spelling oxford-uuid:6745ef0c-ddb2-4345-b249-d07619a919b62022-03-26T18:37:10ZOrbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6745ef0c-ddb2-4345-b249-d07619a919b6EnglishSymplectic Elements at Oxford2007Baxter, MGGaffan, DKyriazis, DMitchell, AThe orbital prefrontal cortex is thought to be involved in behavioral flexibility in primates, and human neuroimaging studies have identified orbital prefrontal activation during episodic memory encoding. The goal of the present study was to ascertain whether deficits in strategy implementation and episodic memory that occur after ablation of the entire prefrontal cortex can be ascribed to damage to the orbital prefrontal cortex. Rhesus monkeys were preoperatively trained on two behavioral tasks, the performance of both of which is severely impaired by the disconnection of frontal cortex from inferotemporal cortex. In the strategy implementation task, monkeys were required to learn about two categories of objects, each associated with a different strategy that had to be performed to obtain food reward. The different strategies had to be applied flexibly to optimize the rate of reward delivery. In the scene memory task, monkeys learned 20 new object-in-place discrimination problems in each session. Monkeys were tested on both tasks before and after bilateral ablation of orbital prefrontal cortex. These lesions impaired new scene learning but had no effect on strategy implementation. This finding supports a role for the orbital prefrontal cortex in memory but places limits on the involvement of orbital prefrontal cortex in the representation and implementation of behavioral goals and strategies.
spellingShingle Baxter, MG
Gaffan, D
Kyriazis, D
Mitchell, A
Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title_full Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title_fullStr Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title_full_unstemmed Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title_short Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task.
title_sort orbital prefrontal cortex is required for object in place scene memory but not performance of a strategy implementation task
work_keys_str_mv AT baxtermg orbitalprefrontalcortexisrequiredforobjectinplacescenememorybutnotperformanceofastrategyimplementationtask
AT gaffand orbitalprefrontalcortexisrequiredforobjectinplacescenememorybutnotperformanceofastrategyimplementationtask
AT kyriazisd orbitalprefrontalcortexisrequiredforobjectinplacescenememorybutnotperformanceofastrategyimplementationtask
AT mitchella orbitalprefrontalcortexisrequiredforobjectinplacescenememorybutnotperformanceofastrategyimplementationtask