Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased ris...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2022
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| _version_ | 1797110846370873344 |
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| author | Shawer, H Cheng, CW Bailey, MA |
| author_facet | Shawer, H Cheng, CW Bailey, MA |
| author_sort | Shawer, H |
| collection | OXFORD |
| description | The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate the potential association of host genetic polymorphisms of ORAI1 with the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and its associated COVID-19 fatality in UK Biobank participants from white British background. The analysis showed no significant association between ORAI1 variants and COVID-19 positivity or fatality, despite the well-established roles of ORAI1 in immune response and inflammation and the success of ORAI1 inhibition in clinical trials. Our results suggest that the host genetic polymorphisms of ORAI1 are unlikely to be implicated in the broad variability in symptoms severity among afflicted patients. |
| first_indexed | 2024-03-07T08:00:25Z |
| format | Journal article |
| id | oxford-uuid:674ac5aa-7354-4162-8ee7-7fb929756929 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:00:25Z |
| publishDate | 2022 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:674ac5aa-7354-4162-8ee7-7fb9297569292023-09-25T16:13:52ZAbsence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatalityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:674ac5aa-7354-4162-8ee7-7fb929756929EnglishSymplectic ElementsPublic Library of Science2022Shawer, HCheng, CWBailey, MAThe calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate the potential association of host genetic polymorphisms of ORAI1 with the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and its associated COVID-19 fatality in UK Biobank participants from white British background. The analysis showed no significant association between ORAI1 variants and COVID-19 positivity or fatality, despite the well-established roles of ORAI1 in immune response and inflammation and the success of ORAI1 inhibition in clinical trials. Our results suggest that the host genetic polymorphisms of ORAI1 are unlikely to be implicated in the broad variability in symptoms severity among afflicted patients. |
| spellingShingle | Shawer, H Cheng, CW Bailey, MA Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title | Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title_full | Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title_fullStr | Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title_full_unstemmed | Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title_short | Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality |
| title_sort | absence of association between host genetic mutations in the orai1 gene and covid 19 fatality |
| work_keys_str_mv | AT shawerh absenceofassociationbetweenhostgeneticmutationsintheorai1geneandcovid19fatality AT chengcw absenceofassociationbetweenhostgeneticmutationsintheorai1geneandcovid19fatality AT baileyma absenceofassociationbetweenhostgeneticmutationsintheorai1geneandcovid19fatality |