Imaging clinically relevant pain states using arterial spin labeling
Arterial Spin Labeling (ASL) is a perfusion-based functional magnetic resonance imaging technique that uses water in arterial blood as a freely diffusible tracer to measure regional cerebral blood flow (rCBF) noninvasively. To date its application to the study of pain has been relatively limited. Ye...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Wolters Kluwer Health
2019
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| _version_ | 1797073084574859264 |
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| author | Loggia, ML Segerdahl, AR Howard, MA Tracey, I |
| author_facet | Loggia, ML Segerdahl, AR Howard, MA Tracey, I |
| author_sort | Loggia, ML |
| collection | OXFORD |
| description | Arterial Spin Labeling (ASL) is a perfusion-based functional magnetic resonance imaging technique that uses water in arterial blood as a freely diffusible tracer to measure regional cerebral blood flow (rCBF) noninvasively. To date its application to the study of pain has been relatively limited. Yet, ASL possesses key features that make it uniquely positioned to study pain in certain paradigms. For instance, ASL is sensitive to very slowly fluctuating brain signals (in the order of minutes or longer). This characteristic makes ASL particularly suitable to the evaluation of brain mechanisms of tonic experimental, post-surgical and ongoing/or continuously varying pain in chronic or acute pain conditions (whereas BOLD fMRI is better suited to detect brain responses to short-lasting or phasic/evoked pain). Unlike positron emission tomography or other perfusion techniques, ASL allows the estimation of rCBF without requiring the administration of radioligands or contrast agents. Thus, ASL is well suited for within-subject longitudinal designs (e.g., to study evolution of pain states over time, or of treatment effects in clinical trials). ASL is also highly versatile, allowing for novel paradigms exploring a flexible array of pain states, plus it can be used to simultaneously estimate not only pain-related alterations in perfusion but also functional connectivity. In conclusion, ASL can be successfully applied in pain paradigms that would be either challenging or impossible to implement using other techniques. Particularly when used in concert with other neuroimaging techniques, ASL can be a powerful tool in the pain imager's toolbox. |
| first_indexed | 2024-03-06T23:16:55Z |
| format | Journal article |
| id | oxford-uuid:677312cb-d58f-4a46-be22-4f13cfb17f0a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:16:55Z |
| publishDate | 2019 |
| publisher | Wolters Kluwer Health |
| record_format | dspace |
| spelling | oxford-uuid:677312cb-d58f-4a46-be22-4f13cfb17f0a2022-03-26T18:38:20ZImaging clinically relevant pain states using arterial spin labelingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:677312cb-d58f-4a46-be22-4f13cfb17f0aEnglishSymplectic ElementsWolters Kluwer Health2019Loggia, MLSegerdahl, ARHoward, MATracey, IArterial Spin Labeling (ASL) is a perfusion-based functional magnetic resonance imaging technique that uses water in arterial blood as a freely diffusible tracer to measure regional cerebral blood flow (rCBF) noninvasively. To date its application to the study of pain has been relatively limited. Yet, ASL possesses key features that make it uniquely positioned to study pain in certain paradigms. For instance, ASL is sensitive to very slowly fluctuating brain signals (in the order of minutes or longer). This characteristic makes ASL particularly suitable to the evaluation of brain mechanisms of tonic experimental, post-surgical and ongoing/or continuously varying pain in chronic or acute pain conditions (whereas BOLD fMRI is better suited to detect brain responses to short-lasting or phasic/evoked pain). Unlike positron emission tomography or other perfusion techniques, ASL allows the estimation of rCBF without requiring the administration of radioligands or contrast agents. Thus, ASL is well suited for within-subject longitudinal designs (e.g., to study evolution of pain states over time, or of treatment effects in clinical trials). ASL is also highly versatile, allowing for novel paradigms exploring a flexible array of pain states, plus it can be used to simultaneously estimate not only pain-related alterations in perfusion but also functional connectivity. In conclusion, ASL can be successfully applied in pain paradigms that would be either challenging or impossible to implement using other techniques. Particularly when used in concert with other neuroimaging techniques, ASL can be a powerful tool in the pain imager's toolbox. |
| spellingShingle | Loggia, ML Segerdahl, AR Howard, MA Tracey, I Imaging clinically relevant pain states using arterial spin labeling |
| title | Imaging clinically relevant pain states using arterial spin labeling |
| title_full | Imaging clinically relevant pain states using arterial spin labeling |
| title_fullStr | Imaging clinically relevant pain states using arterial spin labeling |
| title_full_unstemmed | Imaging clinically relevant pain states using arterial spin labeling |
| title_short | Imaging clinically relevant pain states using arterial spin labeling |
| title_sort | imaging clinically relevant pain states using arterial spin labeling |
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