Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases
2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-wh...
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Bibliographic Details
| Main Authors: |
Best, D,
Chairatana, P,
Glawar, A,
Crabtree, E,
Butters, T,
Wilson, F,
Yu, C,
Wang, W,
Jia, Y,
Adachi, I,
Kato, A,
Fleet, G |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2010
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