Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases
2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-wh...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797073091713564672 |
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| author | Best, D Chairatana, P Glawar, A Crabtree, E Butters, T Wilson, F Yu, C Wang, W Jia, Y Adachi, I Kato, A Fleet, G |
| author_facet | Best, D Chairatana, P Glawar, A Crabtree, E Butters, T Wilson, F Yu, C Wang, W Jia, Y Adachi, I Kato, A Fleet, G |
| author_sort | Best, D |
| collection | OXFORD |
| description | 2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer l-DGJNAc is a very weak but non-competitive-inhibitor of β-hexosaminidases. © 2010. |
| first_indexed | 2024-03-06T23:17:02Z |
| format | Journal article |
| id | oxford-uuid:677b9294-758a-4bbe-9400-aed2c8cad01c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:17:02Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:677b9294-758a-4bbe-9400-aed2c8cad01c2022-03-26T18:38:34ZSynthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidasesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:677b9294-758a-4bbe-9400-aed2c8cad01cEnglishSymplectic Elements at Oxford2010Best, DChairatana, PGlawar, ACrabtree, EButters, TWilson, FYu, CWang, WJia, YAdachi, IKato, AFleet, G2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer l-DGJNAc is a very weak but non-competitive-inhibitor of β-hexosaminidases. © 2010. |
| spellingShingle | Best, D Chairatana, P Glawar, A Crabtree, E Butters, T Wilson, F Yu, C Wang, W Jia, Y Adachi, I Kato, A Fleet, G Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title | Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title_full | Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title_fullStr | Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title_full_unstemmed | Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title_short | Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases |
| title_sort | synthesis of 2 acetamido 1 2 dideoxy d galacto nojirimycin dgjnac from d glucuronolactone the first sub micromolar inhibitor of α n acetylgalactosaminidases |
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