Extracellular vesicles in pancreatic cancer progression and therapies
Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide due to delayed diagnosis and limited treatments. More than 90% of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). Extensive communication between tumour cells and other cell types in the tumour...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2021
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| _version_ | 1797073122368684032 |
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| author | Chang, C-H Pauklin, S |
| author_facet | Chang, C-H Pauklin, S |
| author_sort | Chang, C-H |
| collection | OXFORD |
| description | Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide due to delayed diagnosis and limited treatments. More than 90% of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). Extensive communication between tumour cells and other cell types in the tumour microenvironment have been identified which regulate cancer hallmarks during pancreatic tumorigenesis via secretory factors and extracellular vesicles (EVs). The EV-capsuled factors not only facilitate tumour growth locally, but also enter circulation and reach distant organs to construct a pre-metastatic niche. In this review, we delineate the key factors in pancreatic ductal adenocarcinoma derived EVs that mediate different tumour processes. Also, we highlight the factors that are related to the crosstalk with cancer stem cells/cancer-initiating cells (CSC/CIC), the subpopulation of cancer cells that can efficiently metastasize and resist currently used chemotherapies. Lastly, we discuss the potential of EV-capsuled factors in early diagnosis and antitumour therapeutic strategies. |
| first_indexed | 2024-03-06T23:17:30Z |
| format | Journal article |
| id | oxford-uuid:67a028d6-db6b-4198-be2f-9d2f28096c0c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:17:30Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:67a028d6-db6b-4198-be2f-9d2f28096c0c2022-03-26T18:39:33ZExtracellular vesicles in pancreatic cancer progression and therapiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:67a028d6-db6b-4198-be2f-9d2f28096c0cEnglishSymplectic ElementsSpringer Nature2021Chang, C-HPauklin, SPancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide due to delayed diagnosis and limited treatments. More than 90% of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). Extensive communication between tumour cells and other cell types in the tumour microenvironment have been identified which regulate cancer hallmarks during pancreatic tumorigenesis via secretory factors and extracellular vesicles (EVs). The EV-capsuled factors not only facilitate tumour growth locally, but also enter circulation and reach distant organs to construct a pre-metastatic niche. In this review, we delineate the key factors in pancreatic ductal adenocarcinoma derived EVs that mediate different tumour processes. Also, we highlight the factors that are related to the crosstalk with cancer stem cells/cancer-initiating cells (CSC/CIC), the subpopulation of cancer cells that can efficiently metastasize and resist currently used chemotherapies. Lastly, we discuss the potential of EV-capsuled factors in early diagnosis and antitumour therapeutic strategies. |
| spellingShingle | Chang, C-H Pauklin, S Extracellular vesicles in pancreatic cancer progression and therapies |
| title | Extracellular vesicles in pancreatic cancer progression and therapies |
| title_full | Extracellular vesicles in pancreatic cancer progression and therapies |
| title_fullStr | Extracellular vesicles in pancreatic cancer progression and therapies |
| title_full_unstemmed | Extracellular vesicles in pancreatic cancer progression and therapies |
| title_short | Extracellular vesicles in pancreatic cancer progression and therapies |
| title_sort | extracellular vesicles in pancreatic cancer progression and therapies |
| work_keys_str_mv | AT changch extracellularvesiclesinpancreaticcancerprogressionandtherapies AT pauklins extracellularvesiclesinpancreaticcancerprogressionandtherapies |