Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significan...

Full description

Bibliographic Details
Main Authors: Maeda, S, Tsukada, S, Kanazawa, A, Sekine, A, Tsunoda, T, Koya, D, Maegawa, H, Kashiwagi, A, Babazono, T, Matsuda, M, Tanaka, Y, Fujioka, T, Hirose, H, Eguchi, T, Ohno, Y, Groves, C, Hattersley, A, Hitman, G, Walker, M, Kaku, K, Iwamoto, Y, Kawamori, R, Kikkawa, R, Kamatani, N, McCarthy, M
Format: Journal article
Language:English
Published: 2005
Description
Summary:To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: chi(2)=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); chi(2)=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); chi(2)=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.

Similar Items