A common variant associated with prostate cancer in European and African populations.
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was assoc...
প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
2006
|
_version_ | 1826276682618634240 |
---|---|
author | Amundadottir, LT Sulem, P Gudmundsson, J Helgason, A Baker, A Agnarsson, B Sigurdsson, A Benediktsdottir, K Cazier, J Sainz, J Jakobsdottir, M Kostic, J Magnusdottir, D Ghosh, S Agnarsson, K Birgisdottir, B Le Roux, L Olafsdottir, A Blondal, T Andresdottir, M Gretarsdottir, O Bergthorsson, J Gudbjartsson, D Gylfason, A Thorleifsson, G |
author_facet | Amundadottir, LT Sulem, P Gudmundsson, J Helgason, A Baker, A Agnarsson, B Sigurdsson, A Benediktsdottir, K Cazier, J Sainz, J Jakobsdottir, M Kostic, J Magnusdottir, D Ghosh, S Agnarsson, K Birgisdottir, B Le Roux, L Olafsdottir, A Blondal, T Andresdottir, M Gretarsdottir, O Bergthorsson, J Gudbjartsson, D Gylfason, A Thorleifsson, G |
author_sort | Amundadottir, LT |
collection | OXFORD |
description | With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. |
first_indexed | 2024-03-06T23:17:35Z |
format | Journal article |
id | oxford-uuid:67a73a19-78e6-472e-9208-dba20f956bc2 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T23:17:35Z |
publishDate | 2006 |
record_format | dspace |
spelling | oxford-uuid:67a73a19-78e6-472e-9208-dba20f956bc22022-03-26T18:39:43ZA common variant associated with prostate cancer in European and African populations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:67a73a19-78e6-472e-9208-dba20f956bc2EnglishSymplectic Elements at Oxford2006Amundadottir, LTSulem, PGudmundsson, JHelgason, ABaker, AAgnarsson, BSigurdsson, ABenediktsdottir, KCazier, JSainz, JJakobsdottir, MKostic, JMagnusdottir, DGhosh, SAgnarsson, KBirgisdottir, BLe Roux, LOlafsdottir, ABlondal, TAndresdottir, MGretarsdottir, OBergthorsson, JGudbjartsson, DGylfason, AThorleifsson, GWith the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. |
spellingShingle | Amundadottir, LT Sulem, P Gudmundsson, J Helgason, A Baker, A Agnarsson, B Sigurdsson, A Benediktsdottir, K Cazier, J Sainz, J Jakobsdottir, M Kostic, J Magnusdottir, D Ghosh, S Agnarsson, K Birgisdottir, B Le Roux, L Olafsdottir, A Blondal, T Andresdottir, M Gretarsdottir, O Bergthorsson, J Gudbjartsson, D Gylfason, A Thorleifsson, G A common variant associated with prostate cancer in European and African populations. |
title | A common variant associated with prostate cancer in European and African populations. |
title_full | A common variant associated with prostate cancer in European and African populations. |
title_fullStr | A common variant associated with prostate cancer in European and African populations. |
title_full_unstemmed | A common variant associated with prostate cancer in European and African populations. |
title_short | A common variant associated with prostate cancer in European and African populations. |
title_sort | common variant associated with prostate cancer in european and african populations |
work_keys_str_mv | AT amundadottirlt acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sulemp acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gudmundssonj acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT helgasona acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT bakera acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT agnarssonb acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sigurdssona acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT benediktsdottirk acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT cazierj acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sainzj acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT jakobsdottirm acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT kosticj acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT magnusdottird acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT ghoshs acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT agnarssonk acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT birgisdottirb acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT lerouxl acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT olafsdottira acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT blondalt acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT andresdottirm acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gretarsdottiro acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT bergthorssonj acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gudbjartssond acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gylfasona acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT thorleifssong acommonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT amundadottirlt commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sulemp commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gudmundssonj commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT helgasona commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT bakera commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT agnarssonb commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sigurdssona commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT benediktsdottirk commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT cazierj commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT sainzj commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT jakobsdottirm commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT kosticj commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT magnusdottird commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT ghoshs commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT agnarssonk commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT birgisdottirb commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT lerouxl commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT olafsdottira commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT blondalt commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT andresdottirm commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gretarsdottiro commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT bergthorssonj commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gudbjartssond commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT gylfasona commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations AT thorleifssong commonvariantassociatedwithprostatecancerineuropeanandafricanpopulations |