Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years

<p>Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function<sup>1</sup>. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of he...

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Κύριοι συγγραφείς: Namburete, AIL, Papież, BW, Fernandes, M, Wyburd, MK, Hesse, LS, Moser, FA, Ismail, LC, Gunier, RB, Squier, W, Ohuma, EO, Carvalho, M, Jaffer, Y, Gravett, M, Wu, Q, Lambert, A, Winsey, A, Restrepo-Méndez, MC, Bertino, E, Purwar, M, Barros, FC, Stein, A, Noble, JA, Molnár, Z, Jenkinson, M, Bhutta, ZA, Papageorghiou, AT, Villar, J, Kennedy, SH
Μορφή: Journal article
Γλώσσα:English
Έκδοση: Springer Nature 2023
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author Namburete, AIL
Papież, BW
Fernandes, M
Wyburd, MK
Hesse, LS
Moser, FA
Ismail, LC
Gunier, RB
Squier, W
Ohuma, EO
Carvalho, M
Jaffer, Y
Gravett, M
Wu, Q
Lambert, A
Winsey, A
Restrepo-Méndez, MC
Bertino, E
Purwar, M
Barros, FC
Stein, A
Noble, JA
Molnár, Z
Jenkinson, M
Bhutta, ZA
Papageorghiou, AT
Villar, J
Kennedy, SH
author_facet Namburete, AIL
Papież, BW
Fernandes, M
Wyburd, MK
Hesse, LS
Moser, FA
Ismail, LC
Gunier, RB
Squier, W
Ohuma, EO
Carvalho, M
Jaffer, Y
Gravett, M
Wu, Q
Lambert, A
Winsey, A
Restrepo-Méndez, MC
Bertino, E
Purwar, M
Barros, FC
Stein, A
Noble, JA
Molnár, Z
Jenkinson, M
Bhutta, ZA
Papageorghiou, AT
Villar, J
Kennedy, SH
author_sort Namburete, AIL
collection OXFORD
description <p>Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function<sup>1</sup>. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women<sup>2</sup>, selected using World Health Organization recommendations for growth standards<sup>3</sup>. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2&thinsp;years of age<sup>4,5</sup>. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline<sup>6,7,8</sup>. The atlas corresponds structurally to published magnetic resonance images<sup>9</sup>, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31&thinsp;weeks&rsquo; gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14&thinsp;weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26&thinsp;weeks&rsquo; gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.</p>
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spelling oxford-uuid:67a7e490-ece4-4c9e-aad6-806b4e1b61952023-12-07T11:12:47ZNormative spatiotemporal fetal brain maturation with satisfactory development at 2 yearsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:67a7e490-ece4-4c9e-aad6-806b4e1b6195EnglishSymplectic ElementsSpringer Nature2023Namburete, AILPapież, BWFernandes, MWyburd, MKHesse, LSMoser, FAIsmail, LCGunier, RBSquier, WOhuma, EOCarvalho, MJaffer, YGravett, MWu, QLambert, AWinsey, ARestrepo-Méndez, MCBertino, EPurwar, MBarros, FCStein, ANoble, JAMolnár, ZJenkinson, MBhutta, ZAPapageorghiou, ATVillar, JKennedy, SH<p>Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function<sup>1</sup>. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women<sup>2</sup>, selected using World Health Organization recommendations for growth standards<sup>3</sup>. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2&thinsp;years of age<sup>4,5</sup>. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline<sup>6,7,8</sup>. The atlas corresponds structurally to published magnetic resonance images<sup>9</sup>, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31&thinsp;weeks&rsquo; gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14&thinsp;weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26&thinsp;weeks&rsquo; gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.</p>
spellingShingle Namburete, AIL
Papież, BW
Fernandes, M
Wyburd, MK
Hesse, LS
Moser, FA
Ismail, LC
Gunier, RB
Squier, W
Ohuma, EO
Carvalho, M
Jaffer, Y
Gravett, M
Wu, Q
Lambert, A
Winsey, A
Restrepo-Méndez, MC
Bertino, E
Purwar, M
Barros, FC
Stein, A
Noble, JA
Molnár, Z
Jenkinson, M
Bhutta, ZA
Papageorghiou, AT
Villar, J
Kennedy, SH
Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title_full Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title_fullStr Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title_full_unstemmed Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title_short Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
title_sort normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
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