Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum

Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine...

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Príomhchruthaitheoirí: Reynolds, JNJ, Avvisati, R, Dodson, PD, Fisher, SD, Oswald, MJ, Wickens, JR
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Springer Nature 2022