Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting preadipocyte proliferation. In addition, GH, acting through IGF-I, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts the inactive glucocorticoid, cortisone (E), to active cortisol (...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Tomlinson, J, Crabtree, N, Clark, P, Holder, G, Toogood, A, Shackleton, C, Stewart, P
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2003

Παρόμοια τεκμήρια

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2001)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2004)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
ανά: Stewart, P, κ.ά.
Έκδοση: (2002)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2000)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2005)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
ανά: Stewart, P, κ.ά.
Έκδοση: (2009)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
ανά: Valsamakis, G, κ.ά.
Έκδοση: (2004)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
ανά: Sinclair, A, κ.ά.
Έκδοση: (2007)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
ανά: Rauz, S, κ.ά.
Έκδοση: (2004)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2010)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2007)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
ανά: Swali, A, κ.ά.
Έκδοση: (2008)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2005)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2004)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
ανά: Draper, N, κ.ά.
Έκδοση: (2003)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
ανά: Tomlinson, J
Έκδοση: (2009)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
ανά: Morgan, SA, κ.ά.
Έκδοση: (2010)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2008)

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
ανά: Tomlinson, J
Έκδοση: (2005)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
ανά: Gathercole, L, κ.ά.
Έκδοση: (2013)

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
ανά: Quinkler, M, κ.ά.
Έκδοση: (2004)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2002)

Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
ανά: Markey KA, κ.ά.
Έκδοση: (2016-04-01)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2006)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
ανά: Lukacik, P, κ.ά.
Έκδοση: (2006)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2001)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
ανά: Morgan, SA, κ.ά.
Έκδοση: (2009)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
ανά: Maser, E, κ.ά.
Έκδοση: (1997)

Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
ανά: Ahmed, A, κ.ά.
Έκδοση: (2010)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
ανά: Hult, M, κ.ά.
Έκδοση: (2004)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1997)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
ανά: Hult, M, κ.ά.
Έκδοση: (2001)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2007)

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
ανά: Wu, X, κ.ά.
Έκδοση: (2007)

Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study
ανά: Crowley, R, κ.ά.
Έκδοση: (2019)