Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting preadipocyte proliferation. In addition, GH, acting through IGF-I, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts the inactive glucocorticoid, cortisone (E), to active cortisol (...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Tomlinson, J, Crabtree, N, Clark, P, Holder, G, Toogood, A, Shackleton, C, Stewart, P
Natura:	Journal article
Lingua:	English
Pubblicazione:	2003

Documenti analoghi

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
di: Tomlinson, J, et al.
Pubblicazione: (2001)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
di: Tomlinson, J, et al.
Pubblicazione: (2004)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
di: Stewart, P, et al.
Pubblicazione: (2002)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
di: Tomlinson, J, et al.
Pubblicazione: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
di: Tomlinson, J, et al.
Pubblicazione: (2000)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
di: Bujalska, I, et al.
Pubblicazione: (2005)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
di: Stewart, P, et al.
Pubblicazione: (2009)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
di: Valsamakis, G, et al.
Pubblicazione: (2004)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
di: Sinclair, A, et al.
Pubblicazione: (2007)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
di: Rauz, S, et al.
Pubblicazione: (2004)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
di: Tomlinson, J, et al.
Pubblicazione: (2010)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
di: Wiegand, S, et al.
Pubblicazione: (2007)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
di: Bujalska, I, et al.
Pubblicazione: (2007)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
di: Wiegand, S, et al.
Pubblicazione: (2007)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
di: Tomlinson, J, et al.
Pubblicazione: (2002)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
di: Swali, A, et al.
Pubblicazione: (2008)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
di: Tomlinson, J, et al.
Pubblicazione: (2005)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
di: Tomlinson, J, et al.
Pubblicazione: (2004)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
di: Draper, N, et al.
Pubblicazione: (2003)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
di: Tomlinson, J
Pubblicazione: (2009)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
di: Morgan, SA, et al.
Pubblicazione: (2010)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
di: Bujalska, I, et al.
Pubblicazione: (2008)

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
di: Tomlinson, J, et al.
Pubblicazione: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
di: Tomlinson, J
Pubblicazione: (2005)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
di: Gathercole, L, et al.
Pubblicazione: (2013)

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
di: Quinkler, M, et al.
Pubblicazione: (2004)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
di: Bujalska, I, et al.
Pubblicazione: (2002)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
di: Bujalska, I, et al.
Pubblicazione: (2006)

Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
di: Markey KA, et al.
Pubblicazione: (2016-04-01)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
di: Lukacik, P, et al.
Pubblicazione: (2006)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
di: Tomlinson, J, et al.
Pubblicazione: (2001)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
di: Morgan, SA, et al.
Pubblicazione: (2009)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
di: Maser, E, et al.
Pubblicazione: (1997)

Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
di: Ahmed, A, et al.
Pubblicazione: (2010)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
di: Hult, M, et al.
Pubblicazione: (2004)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
di: Oppermann, U, et al.
Pubblicazione: (1997)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
di: Hult, M, et al.
Pubblicazione: (2001)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
di: Tomlinson, J, et al.
Pubblicazione: (2007)

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
di: Wu, X, et al.
Pubblicazione: (2007)

Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study
di: Crowley, R, et al.
Pubblicazione: (2019)