Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting preadipocyte proliferation. In addition, GH, acting through IGF-I, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts the inactive glucocorticoid, cortisone (E), to active cortisol (...

Полное описание

Библиографические подробности
Главные авторы:	Tomlinson, J, Crabtree, N, Clark, P, Holder, G, Toogood, A, Shackleton, C, Stewart, P
Формат:	Journal article
Язык:	English
Опубликовано:	2003

Схожие документы

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
по: Tomlinson, J, и др.
Опубликовано: (2001)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
по: Tomlinson, J, и др.
Опубликовано: (2004)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
по: Stewart, P, и др.
Опубликовано: (2002)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
по: Tomlinson, J, и др.
Опубликовано: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
по: Tomlinson, J, и др.
Опубликовано: (2000)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
по: Bujalska, I, и др.
Опубликовано: (2005)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
по: Stewart, P, и др.
Опубликовано: (2009)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
по: Valsamakis, G, и др.
Опубликовано: (2004)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
по: Sinclair, A, и др.
Опубликовано: (2007)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
по: Rauz, S, и др.
Опубликовано: (2004)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
по: Tomlinson, J, и др.
Опубликовано: (2010)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
по: Wiegand, S, и др.
Опубликовано: (2007)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
по: Bujalska, I, и др.
Опубликовано: (2007)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
по: Wiegand, S, и др.
Опубликовано: (2007)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
по: Tomlinson, J, и др.
Опубликовано: (2002)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
по: Swali, A, и др.
Опубликовано: (2008)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
по: Tomlinson, J, и др.
Опубликовано: (2005)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
по: Tomlinson, J, и др.
Опубликовано: (2004)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
по: Tomlinson, J
Опубликовано: (2009)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
по: Morgan, SA, и др.
Опубликовано: (2010)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
по: Draper, N, и др.
Опубликовано: (2003)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
по: Bujalska, I, и др.
Опубликовано: (2008)

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
по: Tomlinson, J, и др.
Опубликовано: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
по: Tomlinson, J
Опубликовано: (2005)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
по: Gathercole, L, и др.
Опубликовано: (2013)

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
по: Quinkler, M, и др.
Опубликовано: (2004)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
по: Bujalska, I, и др.
Опубликовано: (2002)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
по: Bujalska, I, и др.
Опубликовано: (2006)

Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
по: Markey KA, и др.
Опубликовано: (2016-04-01)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
по: Lukacik, P, и др.
Опубликовано: (2006)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
по: Tomlinson, J, и др.
Опубликовано: (2001)

Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells
по: Zhang Ping, и др.
Опубликовано: (2009-05-01)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
по: Morgan, SA, и др.
Опубликовано: (2009)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
по: Maser, E, и др.
Опубликовано: (1997)

Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
по: Ahmed, A, и др.
Опубликовано: (2010)

Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction
по: Telleria Carlos M, и др.
Опубликовано: (2004-05-01)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
по: Hult, M, и др.
Опубликовано: (2004)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
по: Oppermann, U, и др.
Опубликовано: (1997)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
по: Hult, M, и др.
Опубликовано: (2001)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
по: Tomlinson, J, и др.
Опубликовано: (2007)