Investigation of expression quantitative trait loci and regulatory genetic variants in primary human immune cells

Investigation of expression quantitative trait loci and regulatory genetic variants in primary human immune cells

<p>The post human genome sequence era has begun to explore various aspects of the functional genome in relation to disease including gene expression, genetic variation and epigenetics. The genetic determinants of common and complex phenotypes are difficult to resolve even though their heritabi...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Makino, S
Awduron Eraill:	Knight, J
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2013
Pynciau:	Immunology Genetics (medical sciences) Molecular genetics Medical Sciences

Eitemau Tebyg

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Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism
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Genetic studies in ulcerative colitis
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The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits
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Genetic, functional, and phenotypic analysis of human variants in the glucokinase regulatory protein gene
gan: Rees, M, et al.
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Allele specific gene expression in the major histocompatibility complex
gan: Plant, K
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Epigenetic approaches to the study of macrophages in atherosclerosis
gan: Reschen, M
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Epigenetic regulation of the myeloid cell lineage
gan: Pliuskys, L
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Forward genetic and cellular studies of immune regulation: the roles of Carma1, Interleukin-10 and Gimap5
gan: Barnes, MJ
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Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins
gan: Lee, Y, et al.
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Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis
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Analysis of the CD200R family
gan: Akkaya, M
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The identification and characterisation of germline genetic variants that affect human cancer
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Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension
gan: Tzenova Bell, J, et al.
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Genetic susceptibility to endometrial cancer
gan: Cheng, T
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Preimplantation genetic diagnosis - new methods for the detection of genetic abnormalities in human preimplantation embryos
gan: Konstantinidis, M
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Use of genome wide expression profiles in analysis of T cell dysfunction in Hepatitis C virus infection
gan: Gupta, P
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Genetics and pathophysiology of coronal craniosynostosis revealed by next-generation DNA sequencing
gan: Sharma, V
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Bias of selection on human copy-number variants
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Forward genetic analysis of mammalian immunity
gan: Siggs, O, et al.
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Functional analysis of polymorphisms associated with osteoarthritis susceptibility that affect cis-regulation
gan: Wilkins, J
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Genetics of ankylosing spondylitis
gan: Karaderi, T
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Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome
gan: Kvikstad, E, et al.
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Genetics determinants of vaccine responses
gan: O'Connor, D
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Molecular Genetics of Language Impairment
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B cell response to pneumococcal vaccines
gan: Trück, J
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A new era for Type 2 diabetes genetics
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The peoples of Britain: population genetics, archaeology and linguistics
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Genetic mapping of variation in spatial learning in the mouse
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Human population structure and demographic history using genetic markers
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Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
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Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects
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A high-resolution single nucleotide polymorphism genetic map of the mouse genome
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Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.
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Functional conservation of HTLV-1 Rex balances the immune pressure for sequence variation in the Rex gene
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Functional genomics of variation in response to infection: insights into severe sepsis and common variable immune deficiency disorders
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On genetic variants underlying common disease
gan: Hechter, E
Cyhoeddwyd: (2011)

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response.
gan: Matsumiya, M, et al.
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