Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise
Bipolar disorder is a chronic, recurrent mental illness characterized by extreme episodes of depressed and manic mood, interspersed with less severe but highly variable mood fluctuations. Here, we develop a novel mathematical approach for exploring the dynamics of bipolar disorder. We investigate ho...
| Main Authors: | , , , |
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| Format: | Journal article |
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Royal Society
2015
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| _version_ | 1797073169734959104 |
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| author | Bonsall, M Geddes, J Goodwin, G Holmes, E |
| author_facet | Bonsall, M Geddes, J Goodwin, G Holmes, E |
| author_sort | Bonsall, M |
| collection | OXFORD |
| description | Bipolar disorder is a chronic, recurrent mental illness characterized by extreme episodes of depressed and manic mood, interspersed with less severe but highly variable mood fluctuations. Here, we develop a novel mathematical approach for exploring the dynamics of bipolar disorder. We investigate how the dynamics of subjective experience of mood in bipolar disorder can be understood using a relaxation oscillator (RO) framework and test the model against mood time-series fluctuations from a set of individuals with bipolar disorder. We show that variable mood fluctuations in individuals diagnosed with bipolar disorder can be driven by the coupled effects of deterministic dynamics (captured by ROs) and noise. Using a statistical likelihood-based approach, we show that, in general, mood dynamics are described by two independent ROs with differing levels of endogenous variability among individuals. We suggest that this sort of nonlinear approach to bipolar disorder has neurobiological, cognitive and clinical implications for understanding this mental illness through a mechacognitive framework. |
| first_indexed | 2024-03-06T23:18:13Z |
| format | Journal article |
| id | oxford-uuid:67d89cd5-a138-496b-a381-04c0a914b95b |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:18:13Z |
| publishDate | 2015 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:67d89cd5-a138-496b-a381-04c0a914b95b2022-03-26T18:41:04ZBipolar disorder dynamics: affective instabilities, relaxation oscillations and noiseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:67d89cd5-a138-496b-a381-04c0a914b95bSymplectic Elements at OxfordRoyal Society2015Bonsall, MGeddes, JGoodwin, GHolmes, EBipolar disorder is a chronic, recurrent mental illness characterized by extreme episodes of depressed and manic mood, interspersed with less severe but highly variable mood fluctuations. Here, we develop a novel mathematical approach for exploring the dynamics of bipolar disorder. We investigate how the dynamics of subjective experience of mood in bipolar disorder can be understood using a relaxation oscillator (RO) framework and test the model against mood time-series fluctuations from a set of individuals with bipolar disorder. We show that variable mood fluctuations in individuals diagnosed with bipolar disorder can be driven by the coupled effects of deterministic dynamics (captured by ROs) and noise. Using a statistical likelihood-based approach, we show that, in general, mood dynamics are described by two independent ROs with differing levels of endogenous variability among individuals. We suggest that this sort of nonlinear approach to bipolar disorder has neurobiological, cognitive and clinical implications for understanding this mental illness through a mechacognitive framework. |
| spellingShingle | Bonsall, M Geddes, J Goodwin, G Holmes, E Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title | Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title_full | Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title_fullStr | Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title_full_unstemmed | Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title_short | Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise |
| title_sort | bipolar disorder dynamics affective instabilities relaxation oscillations and noise |
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