High-intensity focused ultrasound for the treatment of liver tumours.

High-intensity focused ultrasound (HIFU) has been investigated as a tool for the treatment of cancer for many decades, but is only now beginning to emerge as a potential alternative to conventional therapies. In recent years, clinical trials have evaluated the clinical efficacy of a number of device...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Kennedy, J, Wu, F, ter Haar, G, Gleeson, F, Phillips, R, Middleton, MR, Cranston, D
Ձևաչափ: Journal article
Լեզու:English
Հրապարակվել է: 2004
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author Kennedy, J
Wu, F
ter Haar, G
Gleeson, F
Phillips, R
Middleton, MR
Cranston, D
author_facet Kennedy, J
Wu, F
ter Haar, G
Gleeson, F
Phillips, R
Middleton, MR
Cranston, D
author_sort Kennedy, J
collection OXFORD
description High-intensity focused ultrasound (HIFU) has been investigated as a tool for the treatment of cancer for many decades, but is only now beginning to emerge as a potential alternative to conventional therapies. In recent years, clinical trials have evaluated the clinical efficacy of a number of devices worldwide. In Oxford, UK, we have been using the JC HIFU system (HAIFU Technology Company, Chongqing, PR China) in clinical trials since November 2002. This is the first report of its clinical use outside mainland China. The device is non-invasive, and employs an extracorporeal transducer operating at 0.8-1.6 MHz (aperture 12-15 cm, focal length 9-15 cm), operating clinically at Isp (free field) of 5-15 KWcm(-2). The aims of the trials are to evaluate the safety and performance of the device. Performance is being evaluated through two parallel protocols. One employs radiological assessment of response with the use of follow-up magnetic resonance imaging and microbubble-contrast ultrasound. In the other, histological assessment will be made following elective surgical resection of the HIFU treated tumours. Eleven patients with liver tumours have been treated with HIFU to date. Adverse events include transient pain and minor skin burns. Observed response from the various assessment modalities is discussed.
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spelling oxford-uuid:680c26a9-80b4-4497-abdb-6e7bdaa2527f2022-03-26T18:42:21ZHigh-intensity focused ultrasound for the treatment of liver tumours.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:680c26a9-80b4-4497-abdb-6e7bdaa2527fEnglishSymplectic Elements at Oxford2004Kennedy, JWu, Fter Haar, GGleeson, FPhillips, RMiddleton, MRCranston, DHigh-intensity focused ultrasound (HIFU) has been investigated as a tool for the treatment of cancer for many decades, but is only now beginning to emerge as a potential alternative to conventional therapies. In recent years, clinical trials have evaluated the clinical efficacy of a number of devices worldwide. In Oxford, UK, we have been using the JC HIFU system (HAIFU Technology Company, Chongqing, PR China) in clinical trials since November 2002. This is the first report of its clinical use outside mainland China. The device is non-invasive, and employs an extracorporeal transducer operating at 0.8-1.6 MHz (aperture 12-15 cm, focal length 9-15 cm), operating clinically at Isp (free field) of 5-15 KWcm(-2). The aims of the trials are to evaluate the safety and performance of the device. Performance is being evaluated through two parallel protocols. One employs radiological assessment of response with the use of follow-up magnetic resonance imaging and microbubble-contrast ultrasound. In the other, histological assessment will be made following elective surgical resection of the HIFU treated tumours. Eleven patients with liver tumours have been treated with HIFU to date. Adverse events include transient pain and minor skin burns. Observed response from the various assessment modalities is discussed.
spellingShingle Kennedy, J
Wu, F
ter Haar, G
Gleeson, F
Phillips, R
Middleton, MR
Cranston, D
High-intensity focused ultrasound for the treatment of liver tumours.
title High-intensity focused ultrasound for the treatment of liver tumours.
title_full High-intensity focused ultrasound for the treatment of liver tumours.
title_fullStr High-intensity focused ultrasound for the treatment of liver tumours.
title_full_unstemmed High-intensity focused ultrasound for the treatment of liver tumours.
title_short High-intensity focused ultrasound for the treatment of liver tumours.
title_sort high intensity focused ultrasound for the treatment of liver tumours
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AT middletonmr highintensityfocusedultrasoundforthetreatmentoflivertumours
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