A very stable cyclic DNA miniduplex with just two base pairs.

(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circul...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: El-Sagheer, A, Kumar, R, Findlow, S, Werner, J, Lane, A, Brown, T
Ձևաչափ: Journal article
Լեզու:English
Հրապարակվել է: 2008
Նկարագրություն
Ամփոփում:(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.