A very stable cyclic DNA miniduplex with just two base pairs.
(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circul...
| Główni autorzy: | , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2008
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| _version_ | 1826276827548614656 |
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| author | El-Sagheer, A Kumar, R Findlow, S Werner, J Lane, A Brown, T |
| author_facet | El-Sagheer, A Kumar, R Findlow, S Werner, J Lane, A Brown, T |
| author_sort | El-Sagheer, A |
| collection | OXFORD |
| description | (Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA. |
| first_indexed | 2024-03-06T23:19:41Z |
| format | Journal article |
| id | oxford-uuid:6850f6eb-05be-4610-b78f-39b3b7fc45d5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:19:41Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:6850f6eb-05be-4610-b78f-39b3b7fc45d52022-03-26T18:44:01ZA very stable cyclic DNA miniduplex with just two base pairs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6850f6eb-05be-4610-b78f-39b3b7fc45d5EnglishSymplectic Elements at Oxford2008El-Sagheer, AKumar, RFindlow, SWerner, JLane, ABrown, T(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA. |
| spellingShingle | El-Sagheer, A Kumar, R Findlow, S Werner, J Lane, A Brown, T A very stable cyclic DNA miniduplex with just two base pairs. |
| title | A very stable cyclic DNA miniduplex with just two base pairs. |
| title_full | A very stable cyclic DNA miniduplex with just two base pairs. |
| title_fullStr | A very stable cyclic DNA miniduplex with just two base pairs. |
| title_full_unstemmed | A very stable cyclic DNA miniduplex with just two base pairs. |
| title_short | A very stable cyclic DNA miniduplex with just two base pairs. |
| title_sort | very stable cyclic dna miniduplex with just two base pairs |
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