Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).
BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797073288682274816 |
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| author | Crusius, J Canzian, F Capellá, G Peña, A Pera, G Sala, N Agudo, A Rico, F Del Giudice, G Palli, D Plebani, M Boeing, H Bueno-de-Mesquita, H Carneiro, F Pala, V Save, V Vineis, P Tumino, R Panico, S Berglund, G Manjer, J Stenling, R Hallmans, G Martínez, C Dorronsoro, M |
| author_facet | Crusius, J Canzian, F Capellá, G Peña, A Pera, G Sala, N Agudo, A Rico, F Del Giudice, G Palli, D Plebani, M Boeing, H Bueno-de-Mesquita, H Carneiro, F Pala, V Save, V Vineis, P Tumino, R Panico, S Berglund, G Manjer, J Stenling, R Hallmans, G Martínez, C Dorronsoro, M |
| author_sort | Crusius, J |
| collection | OXFORD |
| description | BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC. |
| first_indexed | 2024-03-06T23:19:55Z |
| format | Journal article |
| id | oxford-uuid:68650f9a-3982-484b-a0ed-ba84d03b6900 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:19:55Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:68650f9a-3982-484b-a0ed-ba84d03b69002022-03-26T18:44:34ZCytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:68650f9a-3982-484b-a0ed-ba84d03b6900EnglishSymplectic Elements at Oxford2008Crusius, JCanzian, FCapellá, GPeña, APera, GSala, NAgudo, ARico, FDel Giudice, GPalli, DPlebani, MBoeing, HBueno-de-Mesquita, HCarneiro, FPala, VSave, VVineis, PTumino, RPanico, SBerglund, GManjer, JStenling, RHallmans, GMartínez, CDorronsoro, M BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC. |
| spellingShingle | Crusius, J Canzian, F Capellá, G Peña, A Pera, G Sala, N Agudo, A Rico, F Del Giudice, G Palli, D Plebani, M Boeing, H Bueno-de-Mesquita, H Carneiro, F Pala, V Save, V Vineis, P Tumino, R Panico, S Berglund, G Manjer, J Stenling, R Hallmans, G Martínez, C Dorronsoro, M Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title | Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title_full | Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title_fullStr | Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title_full_unstemmed | Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title_short | Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| title_sort | cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the european prospective investigation into cancer and nutrition epic eurgast |
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