Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.

The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through...

詳細記述

書誌詳細
主要な著者: Zhang, H, Cordoba, S, Dushek, O, Van Der Merwe, P
フォーマット: Journal article
言語:English
出版事項: 2011