Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples.
Retrospective analysis of chromosomal changes in endometrial carcinoma was performed by fluorescence in situ hybridization on free nuclei isolated from formalin-fixed paraffin-embedded tissue. We examined 23 archival samples for numerical aberrations of chromosomes 1 and 10 with the use of specific...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1797073312558350336 |
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| author | Muresu, R Cossu, A Scarpa, A Volpi, E Rocca, P Pintus, A Tibiletti, MG Tanda, F Pirastu, M Massarelli, G |
| author_facet | Muresu, R Cossu, A Scarpa, A Volpi, E Rocca, P Pintus, A Tibiletti, MG Tanda, F Pirastu, M Massarelli, G |
| author_sort | Muresu, R |
| collection | OXFORD |
| description | Retrospective analysis of chromosomal changes in endometrial carcinoma was performed by fluorescence in situ hybridization on free nuclei isolated from formalin-fixed paraffin-embedded tissue. We examined 23 archival samples for numerical aberrations of chromosomes 1 and 10 with the use of specific DNA probes for the pericentromeric and centromeric regions of these two chromosomes. Numerical aberrations of chromosomes 1 and 10 were detected in 39% of the case analyzed, and the frequency of trisomy 10 tended to increase as the histological grade worsened. Our findings confirm the association of cytogenetic anomalies involving chromosomes 1 and 10 with endometrial carcinoma, as reported by other studies, and suggest that changes in centromere 10 copy number may correlate with the degree of tumor differentiation. |
| first_indexed | 2024-03-06T23:20:16Z |
| format | Journal article |
| id | oxford-uuid:687fdebd-f889-4eab-923d-9646165f1a26 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:20:16Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:687fdebd-f889-4eab-923d-9646165f1a262022-03-26T18:45:17ZNumerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:687fdebd-f889-4eab-923d-9646165f1a26EnglishSymplectic Elements at Oxford1998Muresu, RCossu, AScarpa, AVolpi, ERocca, PPintus, ATibiletti, MGTanda, FPirastu, MMassarelli, GRetrospective analysis of chromosomal changes in endometrial carcinoma was performed by fluorescence in situ hybridization on free nuclei isolated from formalin-fixed paraffin-embedded tissue. We examined 23 archival samples for numerical aberrations of chromosomes 1 and 10 with the use of specific DNA probes for the pericentromeric and centromeric regions of these two chromosomes. Numerical aberrations of chromosomes 1 and 10 were detected in 39% of the case analyzed, and the frequency of trisomy 10 tended to increase as the histological grade worsened. Our findings confirm the association of cytogenetic anomalies involving chromosomes 1 and 10 with endometrial carcinoma, as reported by other studies, and suggest that changes in centromere 10 copy number may correlate with the degree of tumor differentiation. |
| spellingShingle | Muresu, R Cossu, A Scarpa, A Volpi, E Rocca, P Pintus, A Tibiletti, MG Tanda, F Pirastu, M Massarelli, G Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title | Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title_full | Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title_fullStr | Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title_full_unstemmed | Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title_short | Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. |
| title_sort | numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma fluorescence in situ hybridization analysis of 23 archival paraffin embedded samples |
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