Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle
As cells pass through each replication–division cycle, they must be able to postpone further progression if they detect any threats to genome integrity, such as DNA damage or misaligned chromosomes. Once a ‘decision’ is made to proceed, the cell unequivocally enters into a qualitatively different bi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2021
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| _version_ | 1797073321972465664 |
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| author | Novák, B Tyson, JJ |
| author_facet | Novák, B Tyson, JJ |
| author_sort | Novák, B |
| collection | OXFORD |
| description | As cells pass through each replication–division cycle, they must be able to postpone further progression if they detect any threats to genome integrity, such as DNA damage or misaligned chromosomes. Once a ‘decision’ is made to proceed, the cell unequivocally enters into a qualitatively different biochemical state, which makes the transitions from one cell cycle phase to the next switch-like and irreversible. Each transition is governed by a unique signalling network; nonetheless, they share a common characteristic of bistable behaviour, a hallmark of molecular memory devices. Comparing the cell cycle signalling mechanisms acting at the restriction point, G1/S, G2/M and meta-to-anaphase transitions, we deduce a generic network motif of coupled positive and negative feedback loops underlying each transition. |
| first_indexed | 2024-03-06T23:20:24Z |
| format | Journal article |
| id | oxford-uuid:688af53b-3154-4806-9542-5cd5c46e564c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:20:24Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:688af53b-3154-4806-9542-5cd5c46e564c2022-03-26T18:45:33ZMechanisms of signalling-memory governing progression through the eukaryotic cell cycleJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:688af53b-3154-4806-9542-5cd5c46e564cEnglishSymplectic ElementsElsevier2021Novák, BTyson, JJAs cells pass through each replication–division cycle, they must be able to postpone further progression if they detect any threats to genome integrity, such as DNA damage or misaligned chromosomes. Once a ‘decision’ is made to proceed, the cell unequivocally enters into a qualitatively different biochemical state, which makes the transitions from one cell cycle phase to the next switch-like and irreversible. Each transition is governed by a unique signalling network; nonetheless, they share a common characteristic of bistable behaviour, a hallmark of molecular memory devices. Comparing the cell cycle signalling mechanisms acting at the restriction point, G1/S, G2/M and meta-to-anaphase transitions, we deduce a generic network motif of coupled positive and negative feedback loops underlying each transition. |
| spellingShingle | Novák, B Tyson, JJ Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title | Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title_full | Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title_fullStr | Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title_full_unstemmed | Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title_short | Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle |
| title_sort | mechanisms of signalling memory governing progression through the eukaryotic cell cycle |
| work_keys_str_mv | AT novakb mechanismsofsignallingmemorygoverningprogressionthroughtheeukaryoticcellcycle AT tysonjj mechanismsofsignallingmemorygoverningprogressionthroughtheeukaryoticcellcycle |