Axonal damage: a key predictor of outcome in human CNS diseases.
Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple sclerosis and other white-matter diseases (acute haemorrhagic leucoencephalitis, leucodystrophies and cen...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2003
|
| _version_ | 1797073336355782656 |
|---|---|
| author | Medana, I Esiri, M |
| author_facet | Medana, I Esiri, M |
| author_sort | Medana, I |
| collection | OXFORD |
| description | Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple sclerosis and other white-matter diseases (acute haemorrhagic leucoencephalitis, leucodystrophies and central pontine myelinolysis), infections [malaria, acquired immunodeficiency syndrome (AIDS) and infection with human lymphotropic virus type 1 (HTLV-I) causing HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP)] and subcortical ischaemic damage. The evidence for axonal damage and, where available, its correlation with neurological outcome in each of these conditions is reviewed. We consider the possible pathogenetic mechanisms involved and how increasing understanding of these may lead to more effective therapeutic or preventive interventions. |
| first_indexed | 2024-03-06T23:20:37Z |
| format | Journal article |
| id | oxford-uuid:6899ca9e-f27b-4441-9e19-f1bfb857119b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:20:37Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:6899ca9e-f27b-4441-9e19-f1bfb857119b2022-03-26T18:45:56ZAxonal damage: a key predictor of outcome in human CNS diseases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6899ca9e-f27b-4441-9e19-f1bfb857119bEnglishSymplectic Elements at Oxford2003Medana, IEsiri, MAxonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple sclerosis and other white-matter diseases (acute haemorrhagic leucoencephalitis, leucodystrophies and central pontine myelinolysis), infections [malaria, acquired immunodeficiency syndrome (AIDS) and infection with human lymphotropic virus type 1 (HTLV-I) causing HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP)] and subcortical ischaemic damage. The evidence for axonal damage and, where available, its correlation with neurological outcome in each of these conditions is reviewed. We consider the possible pathogenetic mechanisms involved and how increasing understanding of these may lead to more effective therapeutic or preventive interventions. |
| spellingShingle | Medana, I Esiri, M Axonal damage: a key predictor of outcome in human CNS diseases. |
| title | Axonal damage: a key predictor of outcome in human CNS diseases. |
| title_full | Axonal damage: a key predictor of outcome in human CNS diseases. |
| title_fullStr | Axonal damage: a key predictor of outcome in human CNS diseases. |
| title_full_unstemmed | Axonal damage: a key predictor of outcome in human CNS diseases. |
| title_short | Axonal damage: a key predictor of outcome in human CNS diseases. |
| title_sort | axonal damage a key predictor of outcome in human cns diseases |
| work_keys_str_mv | AT medanai axonaldamageakeypredictorofoutcomeinhumancnsdiseases AT esirim axonaldamageakeypredictorofoutcomeinhumancnsdiseases |