Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration

<p><strong>Background</strong> Low pH suppresses the proliferation and cytotoxic activity of CD8+ cytotoxic and natural killer lymphocytes. The hypoxia-regulated transmembrane protein, carbonic anhydrase CA9, converts carbon dioxide produced by the Krebs cycle to bicarbonate and pr...

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Main Authors: Giatromanolaki, A, Harris, AL, Banham, AH, Contrafouris, CA, Koukourakis, MI
פורמט: Journal article
שפה:English
יצא לאור: Springer Nature 2020