Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria

Plasmids are thought to play a key role in bacterial evolution by acting as vehicles for horizontal gene transfer, but the role of plasmids as catalysts of gene evolution remains unexplored. We challenged populations of E. coli carrying blaTEM-1 β- lactamase gene on either the chromosome or a multic...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: San Millan, A, Escudero, J, Gifford, D, Mazel, D, MacLean, C
التنسيق: Journal article
منشور في: Springer Nature 2016