Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean

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Several human genetic disorders of hemoglobin have risen in frequency because of the protection they offer against death from malaria, sickle-cell anaemia being a canonical example. Here we address the issue of why this highly protective mutant, present at high frequencies in subSaharan Africa, is u...

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Dettagli Bibliografici
Autori principali:	Penman, B, Pybus, O, Weatherall, D, Gupta, S
Natura:	Journal article
Lingua:	English
Pubblicazione:	National Academy of Sciences of the United States 2009
Soggetti:	Zoological sciences

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