Abstract LB-068: From intracellular antibody fragments to small molecule inhibitors of mutant KRAS

Míreanna comhchosúla

• Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
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  Foilsithe / Cruthaithe: (2018)
• Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
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• BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
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• A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
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• Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
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