Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
Κύριοι συγγραφείς: | Elliott, PR, Leske, D, Wagstaff, J, Schlicher, L, Berridge, G, Maslen, S, Timmermann, F, Ma, B, Fischer, R, Freund, SMV, Komander, D, Gyrd-Hansen, M |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
Cell Press
2021
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Παρόμοια τεκμήρια
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SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling
ανά: Elliott, P, κ.ά.
Έκδοση: (2016) -
CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling
ανά: Gyrd-Hansen, M, κ.ά.
Έκδοση: (2016) -
Regulation of the deubiquitinase CYLD in innate immune signalling
ανά: Leske, D
Έκδοση: (2018) -
The role of CYLD in macrophages
ανά: Zucca, M
Έκδοση: (2018) -
All roads lead to ubiquitin
ανά: Gyrd-Hansen, M
Έκδοση: (2017)