Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
Main Authors: | Elliott, PR, Leske, D, Wagstaff, J, Schlicher, L, Berridge, G, Maslen, S, Timmermann, F, Ma, B, Fischer, R, Freund, SMV, Komander, D, Gyrd-Hansen, M |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
Cell Press
2021
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פריטים דומים
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SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling
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CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling
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Regulation of the deubiquitinase CYLD in innate immune signalling
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Molecular basis and regulation of OTULIN-LUBAC interaction
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All roads lead to ubiquitin
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