Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
मुख्य लेखकों: | Elliott, PR, Leske, D, Wagstaff, J, Schlicher, L, Berridge, G, Maslen, S, Timmermann, F, Ma, B, Fischer, R, Freund, SMV, Komander, D, Gyrd-Hansen, M |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
Cell Press
2021
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समान संसाधन
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SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling
द्वारा: Elliott, P, और अन्य
प्रकाशित: (2016) -
CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling
द्वारा: Gyrd-Hansen, M, और अन्य
प्रकाशित: (2016) -
Regulation of the deubiquitinase CYLD in innate immune signalling
द्वारा: Leske, D
प्रकाशित: (2018) -
Molecular basis and regulation of OTULIN-LUBAC interaction
द्वारा: Elliott, PR, और अन्य
प्रकाशित: (2014) -
All roads lead to ubiquitin
द्वारा: Gyrd-Hansen, M
प्रकाशित: (2017)