IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797073416561360896 |
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| author | Rinaldi, S Peeters, P Berrino, F Dossus, L Biessy, C Olsen, A Tjonneland, A Overvad, K Clavel-Chapelon, F Boutron-Ruault, M Téhard, B Nagel, G Linseisen, J Boeing, H Lahmann, P Trichopoulou, A Trichopoulos, D Koliva, M Palli, D Panico, S Tumino, R Sacerdote, C Gils, v van Noord, P Grobbee, D |
| author_facet | Rinaldi, S Peeters, P Berrino, F Dossus, L Biessy, C Olsen, A Tjonneland, A Overvad, K Clavel-Chapelon, F Boutron-Ruault, M Téhard, B Nagel, G Linseisen, J Boeing, H Lahmann, P Trichopoulou, A Trichopoulos, D Koliva, M Palli, D Panico, S Tumino, R Sacerdote, C Gils, v van Noord, P Grobbee, D |
| author_sort | Rinaldi, S |
| collection | OXFORD |
| description | Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women. |
| first_indexed | 2024-03-06T23:21:49Z |
| format | Journal article |
| id | oxford-uuid:68fb877c-740c-4fc3-a6b0-978bad9804fa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:21:49Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:68fb877c-740c-4fc3-a6b0-978bad9804fa2022-03-26T18:48:36ZIGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:68fb877c-740c-4fc3-a6b0-978bad9804faEnglishSymplectic Elements at Oxford2006Rinaldi, SPeeters, PBerrino, FDossus, LBiessy, COlsen, ATjonneland, AOvervad, KClavel-Chapelon, FBoutron-Ruault, MTéhard, BNagel, GLinseisen, JBoeing, HLahmann, PTrichopoulou, ATrichopoulos, DKoliva, MPalli, DPanico, STumino, RSacerdote, CGils, vvan Noord, PGrobbee, DBlood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women. |
| spellingShingle | Rinaldi, S Peeters, P Berrino, F Dossus, L Biessy, C Olsen, A Tjonneland, A Overvad, K Clavel-Chapelon, F Boutron-Ruault, M Téhard, B Nagel, G Linseisen, J Boeing, H Lahmann, P Trichopoulou, A Trichopoulos, D Koliva, M Palli, D Panico, S Tumino, R Sacerdote, C Gils, v van Noord, P Grobbee, D IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title | IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full | IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_fullStr | IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full_unstemmed | IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_short | IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_sort | igf i igfbp 3 and breast cancer risk in women the european prospective investigation into cancer and nutrition epic |
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