Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

The accumulation of improperly folded proteins within the endoplasmic reticulum (ER) generates perturbations known as ER stress that engage the unfolded protein response. ER stress is involved in many inflammatory pathologies that are also associated with the production of the proinflammatory cytoki...

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Bibliographic Details
Main Authors: Shenderov, K, Riteau, N, Yip, R, Mayer-Barber, K, Oland, S, Hieny, S, Fitzgerald, P, Oberst, A, Dillon, C, Green, DR, Cerundolo, V, Sher, A
Format: Journal article
Language:English
Published: 2014

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