Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

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Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subseq...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Ögmundsdóttir, M, Heublein, S, Kazi, S, Reynolds, B, Visvalingam, S, Shaw, M, Goberdhan, D
التنسيق: Journal article
اللغة:English
منشور في: Public Library of Science 2012

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