T regulatory cells and the control of alloimmunity: from characterisation to clinical application.
T regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance. Recent findings in experimental transplant models combined with the development of functional reporter mice have opened new avenues to study Treg biology and their therapeutic potential. In...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797073433247350784 |
|---|---|
| author | Wieckiewicz, J Goto, R Wood, K |
| author_facet | Wieckiewicz, J Goto, R Wood, K |
| author_sort | Wieckiewicz, J |
| collection | OXFORD |
| description | T regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance. Recent findings in experimental transplant models combined with the development of functional reporter mice have opened new avenues to study Treg biology and their therapeutic potential. In particular, recent advances in understanding Treg function and lineage stability revealed unexpected plasticity of this lineage. Nevertheless, pre-clinical and pilot clinical trials using Treg cells as cellular therapies have been initiated suggesting the safety and feasibility of such treatment. |
| first_indexed | 2024-03-06T23:22:04Z |
| format | Journal article |
| id | oxford-uuid:6912867d-b72f-425a-b55e-1b8bb7903d59 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:22:04Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:6912867d-b72f-425a-b55e-1b8bb7903d592022-03-26T18:49:00ZT regulatory cells and the control of alloimmunity: from characterisation to clinical application.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6912867d-b72f-425a-b55e-1b8bb7903d59EnglishSymplectic Elements at Oxford2010Wieckiewicz, JGoto, RWood, KT regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance. Recent findings in experimental transplant models combined with the development of functional reporter mice have opened new avenues to study Treg biology and their therapeutic potential. In particular, recent advances in understanding Treg function and lineage stability revealed unexpected plasticity of this lineage. Nevertheless, pre-clinical and pilot clinical trials using Treg cells as cellular therapies have been initiated suggesting the safety and feasibility of such treatment. |
| spellingShingle | Wieckiewicz, J Goto, R Wood, K T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title | T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title_full | T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title_fullStr | T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title_full_unstemmed | T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title_short | T regulatory cells and the control of alloimmunity: from characterisation to clinical application. |
| title_sort | t regulatory cells and the control of alloimmunity from characterisation to clinical application |
| work_keys_str_mv | AT wieckiewiczj tregulatorycellsandthecontrolofalloimmunityfromcharacterisationtoclinicalapplication AT gotor tregulatorycellsandthecontrolofalloimmunityfromcharacterisationtoclinicalapplication AT woodk tregulatorycellsandthecontrolofalloimmunityfromcharacterisationtoclinicalapplication |