Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

AIMS:<br>GITR-a co-stimulatory immune checkpoint protein-is known for both its activating and regulating effects on T-cells. As atherosclerosis bears features of chronic inflammation and autoimmunity, we investigated the relevance of GITR in cardiovascular disease (CVD). <br><br>ME...

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Bibliographic Details
Main Authors: Shami, A, Atzler, D, Bosmans, LA, Winkels, H, Meiler, S, Lacy, M, van Tiel, C, Ta Megens, R, Nitz, K, Baardman, J, Kusters, P, Seijkens, T, Buerger, C, Janjic, A, Riccardi, C, Edsfeldt, A, Monaco, C, Daemen, M, de Winther, MPJ, Nilsson, J, Weber, C, Gerdes, N, Gonçalves, I, Lutgens, E
Format: Journal article
Language:English
Published: Oxford University Press 2020

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