Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

OBJECTIVE: The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-...

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Main Authors: Nielsen, L, Ploug, K, Swift, P, Ørskov, C, Jansen-Olesen, I, Chiarelli, F, Holst, J, Hougaard, P, Pörksen, S, Holl, R, de Beaufort, C, Gammeltoft, S, Rorsman, P, Mortensen, H, Hansen, L
Format: Journal article
Language:English
Published: 2007

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