Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria
Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emerge...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2023
|
| _version_ | 1824458691476193280 |
|---|---|
| author | Olawoye, IB Oluniyi, PE Oguzie, JU Uwanibe, JN Kayode, TA Olumade, TJ Ajogbasile, FV Parker, E Eromon, PE Abechi, P Sobajo, TA Ugwu, CA George, UE Ayoade, F Akano, K Oyejide, NE Nosamiefan, I Fred-Akintunwa, I Adedotun-Sulaiman, K Brimmo, FB Adegboyega, BB Philip, C Adeleke, RA Chukwu, GC Ahmed, MI Ope-Ewe, OO Otitoola, SG Ogunsanya, OA Saibu, MF Sijuwola, AE Ezekiel, GO John, OG Akin-John, JO Akinlo, OO Fayemi, OO Ipaye, TO Nwodo, DC Omoniyi, AE Omwanghe, IB Terkuma, CA Okolie, J Ayo-Ale, O Ikponmwosa, O Benevolence, E Naregose, GO Patience, AE Blessing, O Micheal, A Jacqueline, A Aiyepada, JO Abejegah, C Adetifa, IM |
| author_facet | Olawoye, IB Oluniyi, PE Oguzie, JU Uwanibe, JN Kayode, TA Olumade, TJ Ajogbasile, FV Parker, E Eromon, PE Abechi, P Sobajo, TA Ugwu, CA George, UE Ayoade, F Akano, K Oyejide, NE Nosamiefan, I Fred-Akintunwa, I Adedotun-Sulaiman, K Brimmo, FB Adegboyega, BB Philip, C Adeleke, RA Chukwu, GC Ahmed, MI Ope-Ewe, OO Otitoola, SG Ogunsanya, OA Saibu, MF Sijuwola, AE Ezekiel, GO John, OG Akin-John, JO Akinlo, OO Fayemi, OO Ipaye, TO Nwodo, DC Omoniyi, AE Omwanghe, IB Terkuma, CA Okolie, J Ayo-Ale, O Ikponmwosa, O Benevolence, E Naregose, GO Patience, AE Blessing, O Micheal, A Jacqueline, A Aiyepada, JO Abejegah, C Adetifa, IM |
| author_sort | Olawoye, IB |
| collection | OXFORD |
| description | Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates. |
| first_indexed | 2025-02-19T04:29:55Z |
| format | Journal article |
| id | oxford-uuid:694afc64-91f3-46f7-8ea3-4b4b90f0ce1d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:29:55Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:694afc64-91f3-46f7-8ea3-4b4b90f0ce1d2025-01-02T16:21:30ZEmergence and spread of two SARS-CoV-2 variants of interest in NigeriaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:694afc64-91f3-46f7-8ea3-4b4b90f0ce1dEnglishSymplectic ElementsSpringer Nature2023Olawoye, IBOluniyi, PEOguzie, JUUwanibe, JNKayode, TAOlumade, TJAjogbasile, FVParker, EEromon, PEAbechi, PSobajo, TAUgwu, CAGeorge, UEAyoade, FAkano, KOyejide, NENosamiefan, IFred-Akintunwa, IAdedotun-Sulaiman, KBrimmo, FBAdegboyega, BBPhilip, CAdeleke, RAChukwu, GCAhmed, MIOpe-Ewe, OOOtitoola, SGOgunsanya, OASaibu, MFSijuwola, AEEzekiel, GOJohn, OGAkin-John, JOAkinlo, OOFayemi, OOIpaye, TONwodo, DCOmoniyi, AEOmwanghe, IBTerkuma, CAOkolie, JAyo-Ale, OIkponmwosa, OBenevolence, ENaregose, GOPatience, AEBlessing, OMicheal, AJacqueline, AAiyepada, JOAbejegah, CAdetifa, IMIdentifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates. |
| spellingShingle | Olawoye, IB Oluniyi, PE Oguzie, JU Uwanibe, JN Kayode, TA Olumade, TJ Ajogbasile, FV Parker, E Eromon, PE Abechi, P Sobajo, TA Ugwu, CA George, UE Ayoade, F Akano, K Oyejide, NE Nosamiefan, I Fred-Akintunwa, I Adedotun-Sulaiman, K Brimmo, FB Adegboyega, BB Philip, C Adeleke, RA Chukwu, GC Ahmed, MI Ope-Ewe, OO Otitoola, SG Ogunsanya, OA Saibu, MF Sijuwola, AE Ezekiel, GO John, OG Akin-John, JO Akinlo, OO Fayemi, OO Ipaye, TO Nwodo, DC Omoniyi, AE Omwanghe, IB Terkuma, CA Okolie, J Ayo-Ale, O Ikponmwosa, O Benevolence, E Naregose, GO Patience, AE Blessing, O Micheal, A Jacqueline, A Aiyepada, JO Abejegah, C Adetifa, IM Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title | Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title_full | Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title_fullStr | Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title_full_unstemmed | Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title_short | Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria |
| title_sort | emergence and spread of two sars cov 2 variants of interest in nigeria |
| work_keys_str_mv | AT olawoyeib emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT oluniyipe emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT oguzieju emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT uwanibejn emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT kayodeta emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT olumadetj emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ajogbasilefv emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT parkere emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT eromonpe emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT abechip emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT sobajota emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ugwuca emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT georgeue emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ayoadef emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT akanok emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT oyejidene emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT nosamiefani emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT fredakintunwai emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT adedotunsulaimank emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT brimmofb emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT adegboyegabb emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT philipc emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT adelekera emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT chukwugc emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ahmedmi emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT opeeweoo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT otitoolasg emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ogunsanyaoa emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT saibumf emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT sijuwolaae emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ezekielgo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT johnog emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT akinjohnjo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT akinlooo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT fayemioo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ipayeto emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT nwododc emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT omoniyiae emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT omwangheib emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT terkumaca emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT okoliej emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ayoaleo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT ikponmwosao emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT benevolencee emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT naregosego emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT patienceae emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT blessingo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT micheala emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT jacquelinea emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT aiyepadajo emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT abejegahc emergenceandspreadoftwosarscov2variantsofinterestinnigeria AT adetifaim emergenceandspreadoftwosarscov2variantsofinterestinnigeria |