HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may influence thymic selection to increase the frequency of T cell receptors (TCRs) reactive to autoantigens (central hypothesis). However, research in human autoimmunity has provide...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Ishigaki, K, Lagattuta, KA, Luo, Y, James, EA, Buckner, JH, Raychaudhuri, S
Format:	Journal article
Sprache:	English
Veröffentlicht:	Springer Nature 2022

Ähnliche Einträge

Ha-ras hypervariable alleles in myelodysplasia.
von: Thein, S, et al.
Veröffentlicht: (1986)

HLA Alleles Associate with Insulin Autoimmune Syndrome
von: Yao D, et al.
Veröffentlicht: (2024-09-01)

The genetic basis of autoimmunity seen through the lens of T cell functional traits
von: Kaitlyn A. Lagattuta, et al.
Veröffentlicht: (2024-02-01)

Autoimmune HLA Alleles and Neoepitope Presentation Predict Post-Allogenic Transplant Relapse
von: Andrea Castro, et al.
Veröffentlicht: (2023-08-01)

The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.
von: Crawford, H, et al.
Veröffentlicht: (2011)

The complementarity-determining region sequences in IgY antivenom hypervariable regions
von: David Gitirana da Rocha, et al.
Veröffentlicht: (2017-08-01)

Association of HLA alleles with autism
von: Sayad A, et al.
Veröffentlicht: (2018-11-01)

Inferring microevolutionary patterns from allele-size frequency distributions of minisatellite loci: a worldwide study of the APOB 3' hypervariable region polymorphism.
von: Destro-Bisol, G, et al.
Veröffentlicht: (2000)

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
von: Leslie, A, et al.
Veröffentlicht: (2006)

V9 Hypervariable Region Metabarcoding Primers for Euglenozoa and Metamonada
von: Jiří Novák, et al.
Veröffentlicht: (2024-09-01)

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides
von: Yang, X, et al.
Veröffentlicht: (2022)

HLA alleles, especially amino-acid signatures of HLA-DPB1, might contribute to the molecular pathogenesis of early-onset autoimmune thyroid disease.
von: Dong-Hwan Shin, et al.
Veröffentlicht: (2019-01-01)

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
von: Alexander T. Baker, et al.
Veröffentlicht: (2019-02-01)

The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action.
von: Gough, S, et al.
Veröffentlicht: (2007)

Linkage disequilibrium and age of HLA region SNPs in relation to classic HLA gene alleles within Europe.
von: Evseeva, I, et al.
Veröffentlicht: (2010)

Comparison of HLA allelic imputation programs.
von: Jason H Karnes, et al.
Veröffentlicht: (2017-01-01)

HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto’s Thyroiditis and Basedow–Graves Disease
von: Alin-Dan Chiorean, et al.
Veröffentlicht: (2024-03-01)

HLA-DRB1 allelic epitopes that associate with autoimmune disease risk or protection activate reciprocal macrophage polarization
von: Vincent van Drongelen, et al.
Veröffentlicht: (2021-01-01)

Proline-Rich Hypervariable Region of Hepatitis E Virus: Arranging the Disorder
von: Milagros Muñoz-Chimeno, et al.
Veröffentlicht: (2020-09-01)

Hypervariable region polymorphism of mtDNA of recurrent oral ulceration in Chinese.
von: Mao Sun, et al.
Veröffentlicht: (2012-01-01)

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
von: Michael S. Hwang, et al.
Veröffentlicht: (2021-09-01)

21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules
von: Alexander Hellesen, et al.
Veröffentlicht: (2021-10-01)

Association of HLA-A and Non-Classical HLA Class I Alleles.
von: Federico Carlini, et al.
Veröffentlicht: (2016-01-01)

Identification of a First Human Norovirus CD8+ T Cell Epitope Restricted to HLA-A*0201 Allele
von: Maria Malm, et al.
Veröffentlicht: (2018-11-01)

Statistical methodology in the analysis of relationships between DNA polymorphisms and disease: putative association of Ha-ras-I hypervariable alleles and cancer.
von: Peto, T, et al.
Veröffentlicht: (1988)

The use of the hypervariable P8 region of trnL(UAA) intron for identification of orchid species: Evidence from restriction site polymorphism analysis.
von: Rajkumar Kishor, et al.
Veröffentlicht: (2018-01-01)

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
von: Raj, T., et al.
Veröffentlicht: (2017)

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
von: Ekaterina Alexandrovna Repina, et al.
Veröffentlicht: (2013-12-01)

High resolution allele frequency analysis of HLA-A, HLA-B, HLA-DRB1, HLA-C, HLA-DQB1 and HLA-DPB1 in Guangdong Cord Blood Bank
von: RUI Derong, et al.
Veröffentlicht: (2024-11-01)

HLA Alleles, Genotype and Haplotype Analyzes from Central Anatolia Region of Turkey
von: Emel Yantır, et al.
Veröffentlicht: (2023-09-01)

Sequence Analysis of Mitochondrial DNA Hypervariable Regions Using Infrared Fluorescence Detection
von: David L. Steffens, et al.
Veröffentlicht: (1998-06-01)

Molecular characterization of the hypervariable regions of S1 gene of infectious bronchitis virus isolates
von: NIRANJANA S RAJALAKSHMI, et al.
Veröffentlicht: (2024-02-01)

Sequence polymorphism data of the hypervariable regions of mitochondrial DNA in the Yadav population of Haryana
von: Kapil Verma, et al.
Veröffentlicht: (2018-06-01)

HLA alleles associated with asparaginase hypersensitivity in Chinese children
von: Gilbert T. Chua, et al.
Veröffentlicht: (2021-10-01)

HLA Diversity in Saudi Population: High Frequency of Homozygous HLA Alleles and Haplotypes
von: Aziz Alami Chentoufi, et al.
Veröffentlicht: (2022-06-01)

Associations of HLA alleles with specific language impairment.
von: Nudel, R, et al.
Veröffentlicht: (2014)

HLA and leukemia: is it a simple allelic association?
von: M T Dorak, et al.
Veröffentlicht: (1992-01-01)

Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs.
von: Hawke, S, et al.
Veröffentlicht: (1999)

Hypervariability of accessible and inaccessible conformational space of proteins
von: Ashraya Ravikumar, et al.
Veröffentlicht: (2021-01-01)

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.
von: Paul L Klarenbeek, et al.
Veröffentlicht: (2015-01-01)