Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.

Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.

The small molecule, 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione (A12B4C3), is a potent inhibitor of the phosphatase activity of human polynucleotide kinase/phosphatase (PNKP) in vitro. Kinetic analysis revealed that A12B4C3 acts as a...

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Bibliographic Details
Main Authors:	Freschauf, G, Mani, R, Mereniuk, T, Fanta, M, Virgen, C, Dianov, G, Grassot, J, Hall, D, Weinfeld, M
Format:	Journal article
Language:	English
Published:	2010

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