Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

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The CD40-CD154 pathway is important in the pathogenesis of inflammatory bowel disease. Here we show that injection of an agonistic CD40 mAb to T and B cell-deficient mice was sufficient to induce a pathogenic systemic and intestinal innate inflammatory response that was functionally dependent on tum...

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मुख्य लेखकों: Uhlig, H, McKenzie, B, Hue, S, Thompson, C, Joyce-Shaikh, B, Stepankova, R, Robinson, N, Buonocore, S, Tlaskalova-Hogenova, H, Cua, D, Powrie, F
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2006
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