Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher's infinitesimal model of a large number of genetic variants, each with very small effects, whose causal effects could not be individuall...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Crouch, DJM, Bodmer, WF
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	National Academy of Sciences 2020

Gelijkaardige items

Post‐GWAS Polygenic Risk Score: Utility and Challenges
door: Tuan V Nguyen, et al.
Gepubliceerd in: (2020-11-01)

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics
door: Zijie Zhao, et al.
Gepubliceerd in: (2024-10-01)

Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.
door: Jie Yuan, et al.
Gepubliceerd in: (2020-09-01)

Correction: Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.
door: Jie Yuan, et al.
Gepubliceerd in: (2020-10-01)

GWAS and polygenic risk score of severe COVID-19 in Eastern Europe
door: Elena Kovalenko, et al.
Gepubliceerd in: (2024-09-01)

PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
door: Zijie Zhao, et al.
Gepubliceerd in: (2021-09-01)

Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores
door: Florian Privé, et al.
Gepubliceerd in: (2022-10-01)

Polygene Risk Scores
door: James Woodward, et al.
Gepubliceerd in: (2023-07-01)

GWAS-based polygenic risk scoring for predicting cerebral artery dissection in the Chinese population
door: Shufan Zhang, et al.
Gepubliceerd in: (2024-07-01)

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
door: Hyein Jung, et al.
Gepubliceerd in: (2024-02-01)

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
door: Yanyu Liang, et al.
Gepubliceerd in: (2022-01-01)

Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
door: Bodmer, WF, et al.
Gepubliceerd in: (2020)

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
door: Itziar de Rojas, et al.
Gepubliceerd in: (2021-06-01)

Tuning parameters for polygenic risk score methods using GWAS summary statistics from training data
door: Wei Jiang, et al.
Gepubliceerd in: (2024-01-01)

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
door: Harry Hemingway, et al.
Gepubliceerd in: (2023-07-01)

Multi-PGS enhances polygenic prediction by combining 937 polygenic scores
door: Clara Albiñana, et al.
Gepubliceerd in: (2023-08-01)

Genomic inflation factors under polygenic inheritance
door: Yang, J, et al.
Gepubliceerd in: (2011)

Genomic inflation factors under polygenic inheritance.
door: Yang, J, et al.
Gepubliceerd in: (2011)

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores
door: Madeline L. Page, et al.
Gepubliceerd in: (2022-09-01)

Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
door: A. C. Palk, et al.
Gepubliceerd in: (2019-02-01)

Genome editing, Goldilocks and polygenic risk scores
door: Gyngell, C, et al.
Gepubliceerd in: (2019)

Implementation and implications for polygenic risk scores in healthcare
door: John L. Slunecka, et al.
Gepubliceerd in: (2021-07-01)

On cross-ancestry cancer polygenic risk scores.
door: Lars G Fritsche, et al.
Gepubliceerd in: (2021-09-01)

Polygenic risk scores: a biased prediction?
door: Francisco M. De La Vega, et al.
Gepubliceerd in: (2018-12-01)

On the utilization of polygenic risk scores for therapeutic targeting.
door: Greg Gibson
Gepubliceerd in: (2019-04-01)

Polygenic risk score: use in migraine research
door: Mona Ameri Chalmer, et al.
Gepubliceerd in: (2018-04-01)

Power and predictive accuracy of polygenic risk scores.
door: Frank Dudbridge
Gepubliceerd in: (2013-03-01)

Prospects for using risk scores in polygenic medicine
door: Cathryn M. Lewis, et al.
Gepubliceerd in: (2017-11-01)

Association between polygenic risk score and risk of myopia
door: Ghorbani Mojarrad, N, et al.
Gepubliceerd in: (2019)

Polygenic risk scores and breast cancer risk prediction
door: Eleanor Roberts, et al.
Gepubliceerd in: (2023-02-01)

Polygenic risk scores in the clinic: Translating risk into action
door: Anna C.F. Lewis, et al.
Gepubliceerd in: (2021-10-01)

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
door: Itziar de Rojas, et al.
Gepubliceerd in: (2023-02-01)

Polygenic risk and hazard scores for Alzheimer's disease prediction
door: Leonenko, G, et al.
Gepubliceerd in: (2019)

Multiancestry transferability of a polygenic risk score for diverticulitis
door: Richard Peek, et al.
Gepubliceerd in: (2024-09-01)

Pharmacogenomics polygenic risk score: Ready or not for prime time?
door: Sonal Singh, et al.
Gepubliceerd in: (2024-08-01)

Stacked neural network for predicting polygenic risk score
door: Sun bin Kim, et al.
Gepubliceerd in: (2024-05-01)

Will polygenic risk scores for cancer ever be clinically useful?
door: Amit Sud, et al.
Gepubliceerd in: (2021-05-01)

Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
door: Liu H, et al.
Gepubliceerd in: (2023-11-01)

Generalisation of genomic findings and applications of polygenic risk scores
door: Manuel Corpas, et al.
Gepubliceerd in: (2023-07-01)

Transferability of polygenic risk score among diverse ancestries
door: Xi Cheng, et al.
Gepubliceerd in: (2023-08-01)