Molecular epidemiology of Group A Streptococcus infections in Cambodian children, 2007-2012.
Group A Streptococcus(GAS) is responsible for significant morbidity and mortality globally. Two strong vaccine candidates are currently under evaluation: a 30-valent type–specific M protein–based vaccine and a vaccine targeting the conserved J8 region of M protein. The 30-valent vaccine covers the m...
| Main Authors: | , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Lippincott, Williams & Wilkins
2015
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| 主題: |
| 總結: | Group A Streptococcus(GAS) is responsible for significant morbidity and mortality globally. Two strong vaccine candidates are currently under evaluation: a 30-valent type–specific M protein–based vaccine and a vaccine targeting the conserved J8 region of M protein. The 30-valent vaccine covers the most frequent serotypes circulating in highincome countries, but coverage may be suboptimal in low-income settings with greater GAS emm-type diversity. Sixty-eight allelic variants have been described for J8, and the relation between allelic diversity and vaccine efficacy is unclear. Limited epidemiologic data are available from many regions making vaccine coverage estimates imprecise. There are no previous data for low-income countries in South East Asia. |
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