| Shrnutí: | <strong>Background:</strong> Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. <strong>Methods:</strong> In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the <em>VDR</em>, vitamin D–binding protein (<em>GC</em>), 7-dehydrocholesterol reductase (<em>DHCR7</em>), vitamin D 25-hydroxylase (<em>CYP2R1</em>), and vitamin D 24-hydroxylase (<em>CYP24A1</em>) genes with total and site-specific cancer incidence endpoints. <strong>Results:</strong> Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03–1.39], although this was no longer significant after correcting for multiple testing. <strong>Conclusions:</strong> Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. <strong>Impact:</strong> Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer.
|
|---|