No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults
<strong>Background:</strong> Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. <strong>Methods:</strong> In a population-based cohort study of...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for Cancer Research
2017
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| _version_ | 1826277106433130496 |
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| author | Ordóñez-Mena, J Schöttker, B Saum, K Holleczek, B Burwinkel, B Wang, T Brenner, H |
| author_facet | Ordóñez-Mena, J Schöttker, B Saum, K Holleczek, B Burwinkel, B Wang, T Brenner, H |
| author_sort | Ordóñez-Mena, J |
| collection | OXFORD |
| description | <strong>Background:</strong> Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. <strong>Methods:</strong> In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the <em>VDR</em>, vitamin D–binding protein (<em>GC</em>), 7-dehydrocholesterol reductase (<em>DHCR7</em>), vitamin D 25-hydroxylase (<em>CYP2R1</em>), and vitamin D 24-hydroxylase (<em>CYP24A1</em>) genes with total and site-specific cancer incidence endpoints. <strong>Results:</strong> Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03–1.39], although this was no longer significant after correcting for multiple testing. <strong>Conclusions:</strong> Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. <strong>Impact:</strong> Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer. |
| first_indexed | 2024-03-06T23:23:54Z |
| format | Journal article |
| id | oxford-uuid:69b8abff-8de5-4ccf-aae8-f6a02a3aff0d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:23:54Z |
| publishDate | 2017 |
| publisher | American Association for Cancer Research |
| record_format | dspace |
| spelling | oxford-uuid:69b8abff-8de5-4ccf-aae8-f6a02a3aff0d2022-03-26T18:52:47ZNo association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:69b8abff-8de5-4ccf-aae8-f6a02a3aff0dEnglishSymplectic Elements at OxfordAmerican Association for Cancer Research2017Ordóñez-Mena, JSchöttker, BSaum, KHolleczek, BBurwinkel, BWang, TBrenner, H<strong>Background:</strong> Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. <strong>Methods:</strong> In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the <em>VDR</em>, vitamin D–binding protein (<em>GC</em>), 7-dehydrocholesterol reductase (<em>DHCR7</em>), vitamin D 25-hydroxylase (<em>CYP2R1</em>), and vitamin D 24-hydroxylase (<em>CYP24A1</em>) genes with total and site-specific cancer incidence endpoints. <strong>Results:</strong> Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03–1.39], although this was no longer significant after correcting for multiple testing. <strong>Conclusions:</strong> Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. <strong>Impact:</strong> Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer. |
| spellingShingle | Ordóñez-Mena, J Schöttker, B Saum, K Holleczek, B Burwinkel, B Wang, T Brenner, H No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title | No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title_full | No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title_fullStr | No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title_full_unstemmed | No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title_short | No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |
| title_sort | no association of vitamin d pathway genetic variants with cancer risks in a population based cohort of german older adults |
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